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1

Dihydropyrancarboxamides Related to Zanamivir: A New Series of Inhibitors of Influenza Virus Sialidases. 2. Crystallographic and Molecular Modeling Study of Complexes of 4-Amino-4H-pyran-6-carboxamides and Sialidase from Influenza Virus Types A and B

Taylor, Neil R., Cleasby, Anne, Singh, Onkar, Skarzynski, Tadeusz, Wonacott, Alan J., Smith, Paul W., Sollis, Steven L., Howes, Peter D., Cherry, Peter C., Bethell, Richard

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 194 KB

english, 1998

2

The high-resolution crystal structure of a 24-kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin

Francis T.F. Tsai, Onkar M.P. Singh, Tadeusz Skarzynski, Alan J. Wonacott, Simon Weston, Alec Tucker, Richard A. Pauptit, Alexander L. Breeze, J. Philip Poyser, Ronan O'Brien, John E. Ladbury, Dale B.

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1997

Language:

english

File:

PDF, 347 KB

english, 1997

3

ChemInform Abstract: 4-Acetylamino-3-(imidazol-1-yl)-benzoic Acids as Novel Inhibitors of Influenza Sialidase.

Peter D. Howes, Anne Cleasby, Derek N. Evans, Helen Feilden, Paul W. Smith, Steven L. Sollis, Neil Taylor, Alan J. Wonacott

Journal:

Year:

1999

File:

PDF, 33 KB

1999

4

ChemInform Abstract: Sialidase Inhibitors Related to Zanamivir. Further SAR Studies of 4-Amino-4H-pyran-2-carboxylic Acid-6-propylamides.

Paul G. Wyatt, Barry A. Coomber, Derek N. Evans, Torquil I. Jack, Heather E. Fulton, Alan J. Wonacott, Peter Colman, Jose Varghese

Journal:

Year:

2001

File:

PDF, 30 KB

2001

5

Sialidase inhibitors related to zanamivir. Further SAR studies of 4-amino-4H-pyran-2-carboxylic acid-6-propylamides

Paul G Wyatt, Barry A Coomber, Derek N Evans, Torquil I Jack, Heather E Fulton, Alan J Wonacott, Peter Colman, Jose Varghese

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 469 KB

english, 2001

6

4-Acetylamino-3-(imidazol-1-yl)-benzoic acids as novel inhibitors of influenza sialidase

Peter D Howes, Anne Cleasby, Derek N Evans, Helen Feilden, Paul W Smith, Steven L Sollis, Neil Taylor, Alan J Wonacott

Journal:

European Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 193 KB

english, 1999

7

The X-ray crystal structure of phosphomannose isomerase from Candida albicans at 1.7 Å resolution

Cleasby, Anne, Wonacott, Alan, Skarzynski, Tadeusz, Hubbard, Roderick E., Davies, Gideon J., Proudfoot, Amanda E. I., Bernard, Alain R., Payton, Mark A., Wells, Timothy N.C.

Journal:

Natural Structural Biology

Year:

1996

File:

PDF, 1.63 MB

1996

8

Crystal structure of the Ffh and EF-G binding sites in the conserved domain IV of Escherichia coli 4.5S RNA

Luca Jovine, Tobias Hainzl, Chris Oubridge, William G Scott, Jade Li, Titia K Sixma, Alan Wonacott, Tadeusz Skarzynski, Kiyoshi Nagai

Journal:

Year:

2000

Language:

english

File:

PDF, 708 KB

english, 2000

9

Structure of UDP-N-acetylglucosamine enolpyruvyl transferase, an enzyme essential for the synthesis of bacterial peptidoglycan, complexed with substrate UDP-N-acetylglucosamine and the drug fosfomycin

Tadeusz Skarzynski, Anil Mistry, Alan Wonacott, Susan E Hutchinson, Valerie A Kelly, Kenneth Duncan

Journal:

Year:

1996

Language:

english

File:

PDF, 425 KB

english, 1996

10

Heat Stability of a Tetrameric Enzyme, D-Glyceraldehyde-3-PhosphateDehydrogenase

John E. WALKER, Alan J. WONACOTT, J. Ieuan HARRIS

Journal:

Year:

1980

Language:

english

File:

PDF, 552 KB

english, 1980

11

Crystallization and Preliminary X-ray Analysis of Candida albicans Phosphomannose Isomerase

Shirley Tolley, Gideon Davies, Rod E. Hubbard, David J. Smith, Amanda E.I. Proudfoot, Mark A. Payton, Anne Cleasby, Alan Wonacott, Timothy N.C. Wells

Journal:

Journal of Molecular Biology

Year:

1994

File:

PDF, 94 KB

1994

12

Crystallization of Inhibitor Complexes of an N-Terminal 24 kDa Fragment of the DNA Gyrase B Protein

Richard J. Lewis, Onkar M.P. Singh, Clare V. Smith, Anthony Maxwell, Tadeusz Skarzynski, Alan J. Wonacott, Dale B. Wigley

Journal:

Journal of Molecular Biology

Year:

1994

File:

PDF, 147 KB

1994

13

Crystallization and Preliminary X-ray Diffraction Studies of Human RANTES

Jeffrey P. Shaw, Gitay Kryger, Ann Cleasby, Alan Wonacott, Christine A. Power, Amanda E.I. Proudfoot, Timothy N.C. Wells

Journal:

Journal of Molecular Biology

Year:

1994

File:

PDF, 119 KB

1994

14

X-ray and spectrophotometric studies of the binding of proflavin to the S1 specificity pocket of human α-thrombin

Elena Conti, Claudio Rivetti, Alan Wonacott, Peter Brick

Journal:

Year:

1998

Language:

english

File:

PDF, 247 KB

english, 1998

15

Coenzyme-induced conformational changes in glyceraldehyde-3-phosphate dehydrogenase from Bacillus stearothermophilus

Tadeusz Skarżyński, Alan J. Wonacott

Journal:

Journal of Molecular Biology

Year:

1988

Language:

english

File:

PDF, 9.16 MB

english, 1988

16

Low resolution study of crystalline l-lactate dehydrogenase

Adams, Margaret J., Haas, David J., Jeffery, Barbara A., McPherson, Alexander, Mermall, Hunter L., Rossmann, Michael G., Schevitz, Richard W., Wonacott, Alan J.

Journal:

Journal of Molecular Biology

Year:

1969

Language:

english

File:

PDF, 7.49 MB

english, 1969

17

Crystal Structures of Thrombin Complexed to a Novel Series of Synthetic Inhibitors Containing a 5,5- trans -Lactone Template

Jhoti, Harren, Cleasby, Anne, Reid, Scott, Thomas, Pam J., Weir, Malcolm, Wonacott, Alan

Journal:

Year:

1999

Language:

english

File:

PDF, 165 KB

english, 1999

18

The structure of the nicotinamide-adenine dinucleotide coenzyme when bound to lactate dehydrogenase

Adams, Margaret J., McPherson, Alexander, Rossmann, Michael G., Schevitz, Richard W., Wonacott, Alan J.

Journal:

Journal of Molecular Biology

Year:

1970

Language:

english

File:

PDF, 4.21 MB

english, 1970

19

Atomic co-ordinates for an α-helix: Refinement of the crystal structure of α-poly-l-alanine

Arnott, Struther, Wonacott, Alan J.

Journal:

Journal of Molecular Biology

Year:

1966

Language:

english

File:

PDF, 901 KB

english, 1966

20

X-ray Crystallographic Studies of a Series of Penicillin-Derived Asymmetric Inhibitors of HIV-1 Protease

Jhoti, Harren, Singh, Onkar M. P., Weir, Malcolm P., Cooke, Robert, Murray-Rust, Peter, Wonacott, Alan

Journal:

Year:

1994

Language:

english

File:

PDF, 4.53 MB

english, 1994

21

A series of penicillin-derived C2-symmetric inhibitors of HIV-1 proteinase: structural and modeling studies

Wonacott, Alan, Cooke, Robert, Hayes, Fiona R., Hann, Michael M., Jhoti, Harren, McMeekin, Peter, Mistry, Anil, Murray-Rust, Peter, Singh, Onkar M. P., Weir, Malcolm P.

Journal:

Journal of Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 2.51 MB

english, 1993